Assuntos
Antineoplásicos/farmacologia , Regulação Neoplásica da Expressão Gênica , NF-kappa B/genética , Nitrilas/farmacologia , Proteínas de Fusão Oncogênica/genética , Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética , Sulfonas/farmacologia , Adolescente , Animais , Apoptose/efeitos dos fármacos , Ciclo Celular/efeitos dos fármacos , Criança , Técnicas de Cocultura , Sobrevivência de Enxerto , Humanos , Camundongos , Camundongos SCID , NF-kappa B/antagonistas & inibidores , NF-kappa B/metabolismo , Proteínas de Fusão Oncogênica/metabolismo , Fenótipo , Leucemia-Linfoma Linfoblástico de Células T Precursoras/metabolismo , Leucemia-Linfoma Linfoblástico de Células T Precursoras/patologia , Prognóstico , Transdução de Sinais , Células Estromais/citologia , Células Estromais/metabolismo , Linfócitos T/metabolismo , Linfócitos T/patologia , Transplante Heterólogo , Ensaios Antitumorais Modelo de Xenoenxerto , Adulto JovemAssuntos
Linfoma de Células B/diagnóstico , Neoplasias Hipofisárias/diagnóstico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Líquido Cefalorraquidiano/citologia , Criança , Diagnóstico Diferencial , Humanos , Imunocompetência , Linfoma de Células B/tratamento farmacológico , Linfoma de Células B/patologia , Imageamento por Ressonância Magnética , Masculino , Hipófise , Neoplasias Hipofisárias/tratamento farmacológico , Neoplasias Hipofisárias/patologia , Punção EspinalRESUMO
OBJECTIVE: To evaluate the frequency of headache in patients with hypothyroidism. DESIGN: A prospective study of a cohort of patients with hypothyroidism. SETTING: Outpatients or inpatients in a headache clinic and endocrinological clinic. PATIENTS: 102 adults, ages 35 to 78 (83F, 19M) experiencing clinical and biological hypothyroidism. RESULTS: Thirty-one patients with hypothyroidism of 102 (30%) presented with headache 1 to 2 months after the first symptoms of hypothyroidism. The headache was slight, nonpulsatile, continuous, bilateral, and salicylate responsive and disappeared with thyroid hormone therapy. CONCLUSION: The authors believe there is a prevalence of nonspecific headache in hypothyroidism and that it has a particular response to thyroid hormone therapy. Hypothyroidism is another cephalalgia with an endocrinological cause after menstrual cephalalgia. We suspect a metabolic or vascular pathophysiological process.
Assuntos
Cefaleia/tratamento farmacológico , Hipotireoidismo/tratamento farmacológico , Hormônios Tireóideos/uso terapêutico , Adulto , Idoso , Feminino , França/epidemiologia , Cefaleia/complicações , Cefaleia/epidemiologia , Humanos , Hipotireoidismo/complicações , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Resultado do TratamentoRESUMO
The association between Graves' disease and autoimmune thrombocytopenic purpura is rare and yet more frequent than would be expected from a mere coincidence. The existence of an immunological disorder common to Graves' disease and autoimmune thrombocytopenic purpura and/or a direct responsibility of hyperthyroidism in the genesis of immunological disturbances resulting in autoimmune thrombocytopenic purpura are hypotheses put forward to try and explain why these two pathologies are associated. We report two cases in which the antiplatelet autoimmunity developed independently of the thyroid functional disorder, making it unlikely that hyperthyroidism played a direct role in the occurrence of the immunological disorders responsible for the autoimmune thrombocytopenic purpura. The physiopathology responsible for the Graves' disease-autoimmune thrombocytopenic purpura association remains imperfectly known. The existence of an immunological pathogenetic mechanism underlying both diseases seems to be likely; it probably acts through an antigenic determinant that is common to thyroid cells and platelets.
